Alzheimer's disease: early diagnosis
- an increase in the number of amyloid plaques – aggregates consisting of protein fragments and usually detected in the brain tissue of patients with Alzheimer's disease;a decrease in the concentration of the precursor protein of amyloid plaques in the cerebrospinal fluid, which indicates the movement of this protein into the brain tissue, where the active formation of plaques occurs;
- an increase in the content of tau protein in the cerebrospinal fluid - another protein associated with Alzheimer's disease.
- Various regions of the brain of elderly people with "subjective extinction of cognitive functions" who are carriers of the APOE e4 allele (bottom) show a greater amount of protein deposits compared to the brain of elderly people who do not have this allele (top).
Impact of major Alzheimer's-related gene may be felt years before any symptoms appear.