28 January 2016

What did the "lifetime machine" show?

Study: Aging has no single mechanism

As a result, scientists came to the conclusion that aging does not have a single molecular mechanism – it is a systemic process, and a change in one of the physiological aspects affects all the others.

According to the Medical XPress portal (in a note literally repeating the news ‘Lifespan Machine’ Probes Cause of Aging, published on the Harvard Medical School – VM website) with reference to the journal Nature (Stroustrup et al., The temporal scaling of Caenorhabditis elegans aging – VM), scientists from Harvard Medical School conducted a study, in which the influence of various environmental and genetic factors on life expectancy was studied. To study the dynamics of life from 50 decommissioned flatbed scanners purchased at a stationery store, they built a "Lifetime Machine". Each scanner was prepared to monitor 30 thousand worms in 800 Petri dishes and took readings from 16 of these cups per hour.

Video from the site The C. elegans Lifespan Machine – VM.

Scientists led by Nicholas Stroustrup changed the living conditions of worms: nematodes withstood temperature changes, oxidative stress, changes in nutrition, genetic manipulation. The "machine" recorded the life span in various conditions.

After that, the scientists built bell-shaped curves reflecting the life and death of the subjects.

It turned out that aging does not have a single molecular cause - it is a systemic process involving a complex biological network with several elements. All factors – genetic processes or environmental factors – are equally involved in the mechanism of aging. According to Nicholas Stroustrup, there is a deep interdependence in the physiology of the body: a change in one aspect will entail changes in the whole body. 

Portal "Eternal youth" http://vechnayamolodost.ru
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