"Magnetized" cells for targeted delivery of therapeutic genes

The use of human cells as carriers of therapeutic genes for antitumor gene therapy has long been recognized as a promising approach, but usually the number of modified cells entering the tumor is not enough to destroy it. English scientists from the Universities of Sheffield, Kiel and Nottingham have developed a new method of "magnetic guidance" that will solve this problem.

The method consists in embedding nanomagnets inside monocytes used as carriers of therapeutic genes, and then introducing these cells into the bloodstream. After that, a magnet is placed on the tumor zone, attracting the "magnetized" monocytes to their target.

According to the head of the laboratory where the work was carried out, Professor Claire Lewis, the use of nanoparticles that promote the entry of therapeutically modified cells into the tumor can open a new era of gene therapy. In addition, the proposed technique can be used to treat other diseases, including arthritis and coronary heart disease.

Currently, the authors are studying the possibilities of using the magnetic targeting method for targeted delivery of various antitumor drugs, including those capable of preventing metastasis.

Portal "Eternal youth" www.vechnayamolodost.ru based on the materials of ScienceDaily

23.04.2008